Panitumumab is a monoclonal antibody used for the treatment of metastatic colorectal cancer (mCRC). Panitumumab is an epidermal growth factor receptor (EGFR) antagonist, which works by blocking the growth of cancer cells. It is administered every 14 days as an intravenous (IV) infusion, often with chemotherapy.

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ®) for Colon Cancer and Rectal Cancer recommend panitumumab (VECTIBIX ®) + FOLFOX as a first-line treatment option for certain patients ‡ with WT RAS m CRC 3,4§. Drs. Fakih, Philip, Tauer, de Zarraga, and al‑Rajabi. are paid consultants for Amgen.

Erbitux (cetuximab) injection, for intravenous use [package insert]. Eli Lilly panitumumab for chemotherapy-refractory metastatic colorectal cancer. PLoS. ONE. In 2006, Vectibix was approved for monotherapy by the FDA for the treatment of The FDA-approved Vectibix (panitumumab) package insert has the following 10 May 2020 160 antibodies: focus on panitumumab.

Panitumumab package insert

Presentation: Intravenous infusion. Strength: 20mg. Pack Size: 1 Vial. Pack Insert: No. National Drug Code: No. PI & CMI Trade Names and Active Ingredients containing panitumumab.

1) [PACKAGE INSERT DATA] : VECTIBIX® (panitumumab) solution.[AMGEN INC] One Amgen Center Drive. Thousand Oaks, CA 91320-1799. Thousand Oaks, CA 91320-1799. Revised: 05/2010.

Thousand Oaks, CA; Amgen, Inc; June 2017. Accessed January 2021. 2. Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) panitumumab.

The package inserts for both cetuximab and panitumumab currently list EGFR-expressing metastatic colorectal carcinoma as a primary indication for use of these drugs. Nonetheless, the relationship between EGFR expression and clinical response is far from clear.

Panitumumab has two gamma heavy chains and two kappa light chains.

Day 8 1,000 mg If no infusion-related reaction or an infusion-related See DailyMed package insert.
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Accessed January 2021. 2. Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) panitumumab. no more than two doses of Vectibix, treatment may be resumed at 50% of the original dose.

HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ERBITUXsafely and effectively. See full prescribing information Participants received either FOLFIRI and panitumumab 6 mg/kg once every 2 weeks (Q2W) or irinotecan and panitumumab 9 mg/kg once every 3 weeks (Q3W), and pre-emptive skin treatment which included skin moisturizer, sunscreen, 1% hydrocortisone cream, and an oral antibiotic for 6 weeks starting 24 hours prior to chemotherapy. Package leaflet: Information for the user Cyramza ® 10 mg/ml concentrate for solution for infusion ramucirumab .
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Panitumumab solution should be colorless, but may contain a small amount of visible translucent-to-white, amorphous, proteinaceous particulates. Do not administer if there is any discoloration. Using aseptic technique and a 21-gauge or larger needle, withdraw the necessary amount for a dose of 6 mg/kg.

Quando preparado de acordo com as instruções dadas na secção 6.6, a concentração final de panitumumab não deve exceder 10 mg/ml. Panitumumab is a drug used to treat colorectal cancer that has spread to other areas in the body.

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1 Sep 2020 Prior Authorization Drug Coverage Policy This Drug Coverage Policy provides parameters for the coverage of Vectibix [package insert].

Use sunscreen and wear clothing and hats that will limit exposure to sun; Dosage adjustments may be required serious skin related side effects Vectibix® (panitumumab) is for treating patients with wild-type RAS metastatic colorectal cancer (cancer that has spread outside of the colon and rectum). RAS status is determined by an FDA-approved test. Wild-type RAS is a cancer without mutations in the KRAS and NRAS genes. Vectibix® can be used: • J9303 – Injection, panitumumab, 10 mg; 1 billable unit = 10 mg NDC(s): • Vectibix 100 mg/5 mL solution for injection: 55513-0954-xx • Vectibix 400 mg/20 mL solution for injection: 55513-0956-xx . VII. References (STANDARD) 1. Vectibix [package insert].